Ethyleneimine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A monofunctional alkylating agent with potential antineoplastic activity. Reacting with DNA mainly at guanine and adenine residues, ethylenimine alkylates DNA, thereby producing DNA interstrand crosslinks and DNA breaks, and interfering with DNA replication and cell division. (NCI04)

**Synonyms:** - AZIRIDINE - Aminoethylene - Azacyclopropane - Azirane - Aziridine - Dimethyleneimine - Dimethylenimine - Ethylenimine - Ethylimine