Calicheamicin Gamma 1I

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** An oligosaccharide enediyne antitumor antibiotic isolated from Micromonospora echinospora ssp. Calichensis. Calicheamicin Gamma 1I binds to the minor groove of DNA, resulting in site-specific double-strand breaks and apoptosis. (NCI04)