Enediyne Antineoplastic Antibiotic

**Semantic type:** Chemical Viewed Functionally

**Definition:** An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne core of these antibiotics is converted to a benzene diradical intermediate that removes hydrogens from deoxyriboses along the minor groove of DNA, resulting in single- and double-strand breaks and apoptosis.