Fotemustine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

**Synonyms:** - 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester - FOTEMUSTINE - Muphoran - S 10036 - [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester - diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate - fotemustine