Hepsulfam

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. (NCI04)

**Synonyms:** - 1,7-Heptanediyl Ester Sulfamic Acid - HEPSULFAM - HEPSULFAM - Sulfamic acid, 1,7-heptanediyl ester