Spiromustine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

**Synonyms:** - 1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl - SHM - SPIROMUSTINE - Spirohydantoin Mustard - Spirohydantoin mustard