Treosulfan

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhibits myeloablative and immunosuppressive activities.

**Synonyms:** - (S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate - 1,2,3, 4-Butanetetrol, 1,4-dimethanesulfonate, [R-(R*,S*)]- - Dihydroxybusulfan - Dihydroxybusulfan - Grafapex - L-Threitol 1,4-dimethanesulfonate - Ovastat - TREOSULFAN - Trecondi - Treosulphan - Tresulfon - treosulfan