Piperazinedione

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.

**Synonyms:** - 2, 5-Piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride - 2, 5-piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride - 2,5-Piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3.alpha.(2S*,5R*),6.alpha.(2S*,5R*)]]- (9CI) - 2,5-piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3alpha(2S*,5R*),6alpha(2S*,5R*)]]- (9CI) - 593A - 593A - Compound 593A - Compound 593A - Merck Compound 593A - PZD - PZD dihydrochloride, 3,6-bis(5-chloro-2-piperidinyl)-, dihydrochloride - PZD dihydrochloride, 3,6-bis(5-chloro-2-piperidinyl)-, dihydrochloride