Perfosfamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)

**Synonyms:** - 2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide - 4'-Hydroperoxycyclophosphamide - 4-HC - 4-Hydroperoxycyclophosphamide - 4-Hydroperoxycyclophosphamide - 4-Hydroperoxycyclophosphamide - 4-Pergamid - Hydroperoxycyclophosphamide - PERFOSFAMIDE - Pergamid - cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide - cis-4-hydroperoxycyclophosphamide