Topoisomerase-I Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.

**Synonyms:** - Topoisomerase-I Inhibitors