Imidazole Mustard

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04)

**Synonyms:** - 5-(3,3-BIS(2-CHLORETHYL)-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE - 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4-carboxamide - 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide - 5-[3,3-Bis(2-Chloroethyl)-1-Triazeno]Imidazole-4-Carboxamide - BIC - Imidazole mustard - TIC Mustard - TIC mustard