Ependymoma with Genetic Abnormalities

**Semantic type:** Neoplastic Process

**Definition:** A term that refers to ependymomas associated with the presence of molecular and/or cytogenetic abnormalities. Representative examples include supratentorial ependymomas with ZFTA fusion or YAP1 fusion, spinal cord ependymomas with NF2 mutation, group A (PFA) or group B (PFB) posterior fossa ependymomas, and ependymomas with chromosomal losses and gains (e.g., 22q loss, 6q loss, 1q gain).