Triazene Derivative CB10-277

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04)

**Synonyms:** - 1-p-carboxy-3,3-dimethylphenyltriazine - CB10-277