Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease

**Semantic type:** Neoplastic Process

**Definition:** An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive multicentric Castleman disease. It is characterized by the presence of human herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is usually seen in patients with HIV infection.

**Synonyms:** - Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease