Topotecan Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

**Synonyms:** - (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione Monohydrochloride - Evotopin - Hycamptamine - Hycamtin - Hycamtin - Hycamtin - Nogitecan Hydrochloride - Potactasol - SKF S 104864 A - SKF S-104864-A - SKF S104864A - TOPOTECAN HYDROCHLORIDE - Topotec - Topotecan HCl - Topotecan hydrochloride - topotecan hydrochloride - topotecan hydrochloride (oral)