Aziridinylbenzoquinone RH1

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.

**Synonyms:** - 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone - RH1