Carmustine

**Semantic type:** Hazardous or Poisonous Substance|Pharmacologic Substance

**Definition:** An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)

**Synonyms:** - 1,3-Bis(2-chloroethyl)-1-nitrosourea - 1,3-Bis(beta-chloroethyl)-1-nitrosourea - BCNU - BCNU - Becenum - Becenun - BiCNU - Bis(chloroethyl) Nitrosourea - Bis-Chloronitrosourea - CARMUSTINE - Carmubris - Carmubris - Carmustin - Carmustinum - FDA 0345 - N,N'-Bis(2-chloroethyl)-N-nitrosourea - N,N'-bis(2-chloroethyl)-N-nitrosourea - NSC 409962 - NSC409962 - Nitrourean - Nitrumon - Nitrumon - SK 27702 - SRI 1720 - WR 139021 - WR-139021 - WR139021 - carmustine