Chlorambucil

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)

**Synonyms:** - .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid - .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid - .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid - 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid - 4-[bis(2-chloroethyl)amino]benzenebutanoic acid - 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid - 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid - Alti-chlorambucil - Ambochlorin - Ambochlorin - Amboclorin - Amboclorin - Aminochlorambucil - Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) - Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)- - Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)- - CB 1348 - CB-1348 - CHL - CHLORAMBUCIL - Chlorambucilum - Chloraminophen - Chloraminophen - Chloraminophene - Chloraminophene - Chlorbutin - Chlorbutin - Chlorbutine - Chlorbutine - Chloroambucil - Chlorobutin - Chlorobutin - Chlorobutine - Chlorobutine - Ecloril - Ecloril - Elcoril - Elcoril - Leukeran - Leukeran - Leukersan - Leukersan - Leukoran - Leukoran - Linfolizin - Linfolizin - Linfolysin - Lympholysin - N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid - N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid - Phenylbutyric acid nitrogen mustard - WR-139013 - aminochlorambucil - benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) - butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl) - chlorambucil - chlorbutinum - chloroambucil - gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid - gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid - p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid - p-(N, N-di-2-chloroethyl)aminophenyl butyric acid - p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid - p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid - phenylbutyric acid nitrogen mustard