Clonal T-Cell Receptor Beta Chain Gene Rearrangement

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A molecular abnormality involving rearrangement of the TRB gene that results in the expression of antigen-specific T-cell receptor proteins. This process occurs during the differentiation of T-lymphocytes, such that individual T-cell progenitors, and their descendants, generate clonal populations that express identical forms of the T-cell receptor beta chain protein.

**Synonyms:** - Monoclonal T-Cell Receptor Beta Chain Gene Rearrangement