Cyclophosphamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

**Synonyms:** - (-)-Cyclophosphamide - 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate - 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate - 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate - 2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate - 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate - Asta B 518 - B 518 - B-518 - B518 - Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate - CP monohydrate - CTX - CTX - CYCLO-cell - CYCLOPHOSPHAMIDE - Carloxan - Ciclofosfamida - Ciclofosfamide - Cicloxal - Clafen - Clafen - Claphene - Claphene - Cycloblastin - Cycloblastine - Cyclophospham - Cyclophosphamid monohydrate - Cyclophosphamide Monohydrate - Cyclophosphamidum - Cyclophosphamidum - Cyclophosphan - Cyclophosphan - Cyclophosphane - Cyclophosphanum - Cyclostin - Cyclostin - Cyclostine - Cytophosphan - Cytophosphan - Cytophosphane - Cytoxan - Fosfaseron - Genoxal - Genoxal - Genuxal - Ledoxina - Mitoxan - Mitoxan - N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate - N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate - N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate - N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate - N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate - N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate - Neosar - Neosar - Revimmune - Syklofosfamid - WR 138719 - WR- 138719 - WR-138719 - WR138719 - bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate - cyclophosphamide