Estramustine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)

**Synonyms:** - 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate)) - ESTRAMUSTINE - Estradiol 3-[bis(2-chloroethyl)carbamate] - Leo 275 - RO 21-8837 - estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate] - estradiol 3-bis(2-chloroethyl)carbamate - estramustine