Estramustine Phosphate Sodium

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.

**Synonyms:** - ESTRAMUSTINE PHOSPHATE SODIUM - Emcyt - Estracyt - Estracyt - Estramustine 17-(Dihydrogenphosphate) Disodium Salt - Estramustine Phosphate - Estramustine Sodium Phosphate - Estramustine phosphate - Estramustine sodium phosphate - Leo 299 - Leo-299 - Ro-21-8837/001