Altretamine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)

**Synonyms:** - 2,4,6-Tris(dimethylamino)-s-triazine - 2,4,6-tris(dimethylamino)-s-triazine - ALTRETAMINE - ENT 50852 - ENT-50852 - HMM - HXM - Hemel - Hemel - Hexalen - Hexaloids - Hexamethylamine - Hexamethylmelamine - Hexamethylmelamine - Hexastat - Hexastat - Hexinawas - N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-2,4,6-triamine - N,n,n',N'',N''-hexamethyl-1,3,5,-triazine-2,4,6,-triamine - RB-1515 - WR-95704 - altretamine - s-Triazine, 2,4,6-tris(dimethylamino)-