Ifosfamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)

**Synonyms:** - 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine - 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide - Asta Z 4942 - Asta Z-4942 - Cyfos - Cyfos - Holoxan - Holoxane - IFO - IFO-Cell - IFOSFAMIDE - IFX - Ifex - Ifex - Ifolem - Ifomida - Ifomide - Ifosfamidum - Ifoxan - Iphosphamid - Iphosphamid - Iphosphamide - Iphosphamide - Iso-Endoxan - Isoendoxan - Isoendoxan - Isophosphamide - Isophosphamide - MJF 9325 - MJF-9325 - Mitoxana - Mitoxana - N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide - Naxamide - Naxamide - Seromida - Tronoxal - Z 4942 - Z-4942 - ifosfamide