Mechlorethamine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)

**Synonyms:** - Bis(2-chloroethyl)methylamine - Chlorethazine - Chlormethine - HN 2 - HN2 - MECHLORETHAMINE - Methylbis(beta-chloroethyl)amine - Mustard - Mustine - NITROGEN MUSTARD HN-2 - Nitrogen Mustard - Nitrogen Mustard - chlorethazine - chloromethine - ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl - methylchlorethamine