Mechlorethamine Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.

**Synonyms:** - Bis(2-chloroethyl)methylamine Hydrochloride - Caryolysine - Caryolysine - Chlorethamine HCl - Chlorethazine Hydrochloride - Chlormethine Hydrochloride - Chlormethine hydrochloride - Chloromethine HCl - Chloromethine Hydrochloride - Cloramin - Erasol - Erasol - HN 2 Hydrochloride - MECHLORETHAMINE HYDROCHLORIDE - Mechlorethamine hydrochloride - Methylbis(beta-chloroethyl)amine Hydrochloride - Methylbis(beta-chloroethyl)amine Hydrochloride - Methylchlorethamine Hydrochloride - Mustargen - Mustargen - Mustargen HCl - Mustargen Hydrochloride - Mustargen hydrochloride - Mustine Hydrochloride - Mustine hydrochloride - N-Lost - N-Lost - Onco-Cloramin - WR-147650 - chlorethamine hydrochloride - ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride - mechlorethamine HCl - mechlorethamine hydrochloride - mustine