Melphalan

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

**Synonyms:** - 4-[bis(2-chloroethyl)amino]-L-phenylalanine - Alanine Nitrogen Mustard - CB-3025 - L-PAM - L-Phenylalanine Mustard - L-Phenylalanine mustard - L-Sarcolysin - L-Sarcolysin Phenylalanine mustard - L-Sarcolysine - L-Sarcolysine - L-sarcolysin - MELPHALAN - Melphalan for Injection-Hepatic Delivery System - Melphalanum - Phenylalanine Mustard - Phenylalanine Nitrogen Mustard - Phenylalanine nitrogen mustard - Sarcoclorin - Sarkolysin - Sarkolysin - WR-19813 - melphalan - p-di(chloroethyl)amino-L-phenylalanine