Procarbazine Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

**Synonyms:** - Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) - Ibenzmethyzine hydrochloride - MIH hydrochloride - MIH hydrochloride - Matulane - Matulane - Matulane - N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride - N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride - N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride - NCI C01810 - NCI-C01810 - NCI-C01810 - NCIC01810 - Natulan - Natulan - Natulanar - Natunalar - Natunalar - PCB - PCB Hydrochloride - PCB hydrochloride - PCZ - PROCARBAZINE HYDROCHLORIDE - Ro 4 6467/1 - Ro 4-6467/1 - benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) - p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride - p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride - p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) - p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI) - procarbazine hydrochloride