Semustine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

**Synonyms:** - 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea - 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea - 1-(2-Chloroethyl)-3-(trans-4-methylcyclohexane)-1-nitrosourea - 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea - Lomustine, Methyl - Lomustine, methyl - MCCNU - MeCCNU - MeCCNU - Methyl CCNU - Methyl CCNU - Methyl Lomustine - SEMUSTINE - Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI) - Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI) - methyl-CCNU - semustine - trans-Methyl-CCNU - trans-Methyl-CCNU - urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI) - urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)