Topoisomerase I Inhibitor Genz-644282

**Semantic type:** Pharmacologic Substance

**Definition:** A non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.

**Synonyms:** - GENZ-644282 - Genz-644282