BRCA-Related Cancer Predisposition Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal dominant inherited syndrome caused by deleterious mutations in the BRCA1 or BRCA2 genes. Affected individuals are at high risk of developing breast cancer, particularly before the age of fifty, high risk of developing a second primary breast cancer, and high risk of developing both breast and ovarian cancer.

**Synonyms:** - BRCA-Mutated Malignant Neoplasm - BRCA1/2-Associated Hereditary Breast and Ovarian Cancer Syndrome - Breast and Ovarian Cancer - Breast and Ovarian Cancer Syndrome - Familial Breast and Ovarian Cancer Syndrome - Familial Breast/Ovarian Cancer (BRCA1, BRCA2) - Hereditary Breast and Ovarian Cancer - Hereditary Breast and Ovarian Cancer Syndrome - Hereditary Breast and Ovarian Cancer Syndrome - Hereditary Breast and Ovarian Cancer Syndrome - Hereditary Breast and Ovarian Syndrome - Hereditary Breast/Ovarian Cancer (BRCA1, BRCA2)