Thiotepa

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.

**Synonyms:** - 1,1',1"-phosphinothioylidynetrisaziridine - 1,1',1''-Phosphinothioyldynetrisaziridine - 1,1',1''-Phosphinothioylidynetrisaziridine - Girostan - N,N', N''-Triethylenethiophosphoramide - N,N',N''-triethylenethiophosphoramide - Oncotiotepa - SH 105 - SH-105 - SH105 - STEPA - TESPA - TESPA - THIOTEPA - TIO TEF - TSPA - TSPA - Tepadina - Tepadina - Tepylute - Tespamin - Tespamine - Thio-Tepa - Thiofosfamide - Thiofozil - Thiophosphamide - Thiophosphamide - Thiophosphoamide - Thiophosphoramide - Thioplex - Thiotef - Tifosyl - Tio-tef - Triethylene Thiophosphoramide - Triethylene thiophosphoramide - Triethylenethiophosphoramide - Tris(1-aziridinyl)phosphine sulfide - WR 45312 - thiotepa - triethylenethiophosphoramide - tris(1-aziridinyl)phosphine sulfide