SarCNU

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An alkylating chloroethylnitrosourea with antineoplastic activity. Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

**Synonyms:** - 2-CHLOROETHYL-3-SARCOSINAMIDE-1-NITROSOUREA - 2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea - sarCNU - sarcosinamide nitrosourea