Mitomycin

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)

**Synonyms:** - (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione - Ametycine - Ametycine - Jelmyto - MITO - MITO-C - MITOMYCIN - MITOMYCIN C - Mito-C - Mito-Medac - Mitocin - Mitocin-C - Mitocin-C - Mitolem - Mitomycin C - Mitomycin C - Mitomycin pyelocalyceal - Mitomycin-C - Mitomycin-X - Mitomycine C - Mitosol - Mitozytrex - Mutamycin - Mutamycin - Mutamycine - NCI-C04706 - [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione